| Champ: |  Novak Djokovic |
| Score: | 6–3, 6–4 |
| Draw: | 56 (7 / 4) |
| Seeds: | 16 |
| After Year: | 2021 |
See main article: 2019 Mutua Madrid Open.
Novak Djokovic defeated Stefanos Tsitsipas in the final, 6–3, 6–4 to win the men's singles tennis title at the 2019 Madrid Open. With the win, Djokovic tied Rafael Nadal's record of 33 Masters 1000 singles titles. He did not lose a single set in the entire tournament.
Alexander Zverev was the defending champion,[1] but lost in the quarterfinals to Tsitsipas.
This tournament marked the last professional appearance of David Ferrer;[2] he lost in the second round to Zverev. It was also Roger Federer's first clay court tournament since the 2016 Rome Masters.
The top eight seeds received a bye into the second round.
