| Date: | 1–7 April |
| Edition: | 10th |
| Draw: | 48S / 16D |
| Surface: | Hard |
| Location: | Monterrey, Mexico |
| Champs: |  Alexander Bublik |
| Champd: |  Evan King / Nathan Pasha |
The 2019 Monterrey Challenger was a professional tennis tournament played on hard courts. It was the tenth edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Monterrey, Mexico from 1 to 7 April 2019.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Tennys Sandgren | 91 | 1 | ||
| Bradley Klahn | 93 | 2 | ||
 Spain | Feliciano López | 94 | 3 | |
 Norway | Casper Ruud | 98 | 4 | |
 Italy | Paolo Lorenzi | 107 | 5 | |
| Spain | Marcel Granollers | 111 | 6 | |
| Kazakhstan | Alexander Bublik | 131 | 7 | |
 Canada | Peter Polansky | 138 | 8 | |
| Christopher Eubanks | 150 | 9 | ||
| Mitchell Krueger | 170 | 10 | ||
 Ecuador | Roberto Quiroz | 172 | 11 | |
| Marcos Giron | 173 | 12 | ||
 United Kingdom | James Ward | 177 | 13 | |
| Dominik Köpfer | 182 | 14 | ||
 Austria | Sebastian Ofner | 184 | 15 | |
| Darian King | 191 | 16 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2019 Monterrey Challenger – Singles.
Alexander Bublik def. Emilio Gómez 6–3, 6–2.See main article: 2019 Monterrey Challenger – Doubles.
Evan King / Nathan Pasha def. 
Santiago González / 
Aisam-ul-Haq Qureshi 7–5, 6–2.
