The 2019 Los Cabos Open (also known as the Abierto Mexicano de Tenis Mifel presentado por Cinemex for sponsorship reasons) was an ATP tennis tournament played on outdoor hard courts. It was the 4th edition of the tournament, and part of the ATP Tour 250 series of the 2019 ATP Tour. It took place in Los Cabos, Mexico from July 29 through August 4, 2019.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Fabio Fognini | 10 | 1 | |
 Argentina | Guido Pella | 24 | 2 | |
| Argentina | Diego Schwartzman | 25 | 3 | |
 France | Lucas Pouille | 27 | 4 | |
| Taylor Fritz | 32 | 5 | ||
| Cristian Garín | 37 | 6 | ||
 Moldova, Republic of | Radu Albot | 42 | 7 | |
 Kazakhstan | Mikhail Kukushkin | 45 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry using a protected ranking into the singles main draw:
The following players received entry from the qualifying draw:
Juan Martín del Potro → replaced by Grégoire Barrère| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 United Kingdom | Dominic Inglot | Austin Krajicek | 86 | 1 | ||
| Argentina | Guido Pella | Argentina | Diego Schwartzman | 101 | 2 | |
 Mexico | Santiago González |  Pakistan | Aisam-ul-Haq Qureshi | 111 | 3 | |
 Japan | Ben McLachlan |  Australia | John-Patrick Smith | 122 | 4 |
The following pairs received wildcards into the doubles main draw:
See main article: 2019 Los Cabos Open – Singles.
Diego Schwartzman def. 
Taylor Fritz, 7–6(8–6), 6–3See main article: 2019 Los Cabos Open – Doubles.
Dominic Inglot / Austin Krajicek, 7–5, 5–7, [16–14]
