| Champ: | Belinda Bencic |
| Runner: |  Anastasia Pavlyuchenkova |
| Score: | 3–6, 6–1, 6–1 |
| After Year: | 2021 |
See main article: article and 2019 Kremlin Cup. Daria Kasatkina was the defending champion, but lost in the first round to Dayana Yastremska.[1]
Belinda Bencic won the title, defeating Anastasia Pavlyuchenkova in the final, 3–6, 6–1, 6–1. By defeating Kristina Mladenovic in the semifinals, Bencic qualified and earned the final berth for the 2019 WTA Finals, overtaking both Kiki Bertens and Serena Williams in the WTA race.
The top four seeds received a bye into the second round.