See main article: article and 2019 Knoxville Challenger.
Toshihide Matsui and Frederik Nielsen were the defending champions[1] but chose not to defend their title.
Hans Hach Verdugo and Adrián Menéndez Maceiras won the title after defeating Bradley Klahn and Sem Verbeek 7–6(8–6), 4–6, [10–5] in the final.