| Date: | 4–10 November |
| Edition: | 16th |
| Surface: | Hard |
| Location: | Knoxville, United States |
| Champs: |  Michael Mmoh |
| Champd: |  Hans Hach Verdugo /  Adrián Menéndez Maceiras |
| After Year: | 2021 |
The 2019 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the sixteenth edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Knoxville, United States between 4 and 10 November 2019.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Tommy Paul | 80 | 1 | ||
| Brayden Schnur | 99 | 2 | ||
| Bradley Klahn | 100 | 3 | ||
| Taro Daniel | 110 | 4 | ||
| Denis Kudla | 111 | 5 | ||
| Paolo Lorenzi | 117 | 6 | ||
| Marcos Giron | 125 | 7 | ||
| Christopher O'Connell | 139 | 8 | ||
| Blaž Rola | 140 | 9 | ||
 Ecuador | Gómez | 144 | 10 | |
 Canada | Peter Polansky | 159 | 11 | |
| Darian King | 169 | 12 | ||
| Canada | Vasek Pospisil | 174 | 13 | |
 France | ||||
 Russian Federation | Alexey Vatutin | 197 | 15 | |
| Mitchell Krueger | 201 | 16 |
The following players received wildcards into the singles main draw:
Scott Jones Aleksandar Kovacevic Brandon Nakashima Nathan Ponwith Zachary SvajdaThe following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2019 Knoxville Challenger – Singles.
Michael Mmoh def. Christopher O'Connell 6–4, 6–4.See main article: 2019 Knoxville Challenger – Doubles.
Hans Hach Verdugo / Adrián Menéndez Maceiras def. Bradley Klahn / Sem Verbeek 7–6(8–6), 4–6, [10–5].
