| Date: | 11 November – 17 November |
| Edition: | 24th |
| Surface: | Hard |
| Location: | Champaign, Illinois, United States |
| Champs: |  J. J. Wolf |
| Champd: | Christopher Eubanks / Kevin King |
| After Year: | 2021 |
The 2019 JSM Challenger of Champaign–Urbana was a professional tennis tournament played on hard courts. It was the twenty-fourth edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Champaign, Illinois, United States between November 11 and November 17, 2019.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Denis Kudla | 114 | 1 | ||
| Blaž Rola | 139 | 2 | ||
 Ecuador | Emilio Gómez | 148 | 3 | |
| Mikael Torpegaard | 169 | 4 | ||
 Canada | Peter Polansky | 185 | 5 | |
| Christopher Eubanks | 209 | 6 | ||
 Argentina | Francisco Cerúndolo | 251 | 7 | |
| Argentina | Juan Pablo Ficovich | 253 | 8 | |
| J. J. Wolf | 257 | 9 | ||
 Dominican Republic | Roberto Cid Subervi | 264 | 10 | |
 Japan | Kaichi Uchida | 280 | 11 | |
| Canada | Filip Peliwo | 285 | 12 | |
| JC Aragone | 289 | 13 | ||
| Sebastian Korda | 298 | 14 | ||
| Kevin King | 311 | 15 | ||
| Roy Smith | 329 | 16 |
The following players received wildcards into the singles main draw:
Alexander Brown Aleksandar Kovacevic Austin Rapp Keegan Smith Zachary SvajdaThe following players received entry from the qualifying draw:
William Blumberg Ezekiel ClarkSee main article: 2019 JSM Challenger of Champaign–Urbana – Singles.
J. J. Wolf def. Sebastian Korda 6–4, 6–7(3–7), 7–6(8–6).See main article: 2019 JSM Challenger of Champaign–Urbana – Doubles.
Christopher Eubanks / Kevin King def. 
Evan Hoyt / Martin Redlicki 7–5, 6–3.