| Champ: |  Rafael Nadal |
| Score: | 6–0, 4–6, 6–1 |
| Draw: | 56 (7 / 4) |
| Seeds: | 16 |
| After Year: | 2020 |
See main article: 2019 Italian Open (tennis).
Defending champion Rafael Nadal[1] defeated Novak Djokovic in the final, 6–0, 4–6, 6–1 to win the men's singles tennis title at the 2019 Italian Open. It was his record-extending ninth Italian Open title and record 34th ATP Masters 1000 title.
Nick Kyrgios was defaulted from his second round match after multiple penalties for unsportsmanlike conduct. As a result, Kyrgios forfeited all points and prize money earned from the event.[2]
The top eight seeds receive a bye into the second round.