The 2019 Internazionali di Tennis Città di Perugia was a professional tennis tournament played on clay courts. It was the fifth edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Perugia, Italy between 8 and 14 July 2019.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Federico Delbonis | 75 | 1 | |
 Bosnia and Herzegovina | Damir Džumhur | 91 | 2 | |
 Spain | Albert Ramos Viñolas | 99 | 3 | |
 Italy | Paolo Lorenzi | 106 | 4 | |
| Pedro Sousa | 107 | 5 | ||
| Italy | Salvatore Caruso | 123 | 6 | |
| Italy | Filippo Baldi | 149 | 7 | |
| Italy | Alessandro Giannessi | 160 | 8 | |
| Argentina | Facundo Bagnis | 161 | 9 | |
| Spain | Guillermo García López | 164 | 10 | |
| Italy | Federico Gaio | 174 | 11 | |
| Argentina | Federico Coria | 176 | 12 | |
| Italy | Stefano Napolitano | 177 | 13 | |
 Slovakia | Filip Horanský | 181 | 14 | |
 Ecuador | Emilio Gómez | 184 | 15 | |
 Colombia | Daniel Elahi Galán | 194 | 16 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw using their ITF World Tennis Ranking:
Riccardo Bonadio Raúl Brancaccio Oriol Roca Batalla Pietro Rondoni
Roman SafiullinThe following players received entry from the qualifying draw:
See main article: 2019 Internazionali di Tennis Città di Perugia – Singles.
Federico Delbonis def. Guillermo García López 6–0, 1–6, 7–6(7–5).See main article: 2019 Internazionali di Tennis Città di Perugia – Doubles.
Tomislav Brkić / Ante Pavić def. 
Rogério Dutra Silva / 
Szymon Walków 6–4, 6–3.