| Date: | 1–7 April 2019 |
| Edition: | 6th |
| Surface: | Clay |
| Location: | Palm Harbor, Florida, United States |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $80,000 |
| Champs: |  Barbora Krejčíková |
| Champd: |  Quinn Gleason / Ingrid Neel |
| Before Year: | 2015 |
| After Name: | U.S. Pro Women's Clay Court Championships |
| After Year: | 2022 |
The 2019 Innisbrook Open was a professional tennis tournament played on outdoor clay courts. It was the sixth edition of the tournament which was part of the 2019 ITF Women's World Tennis Tour. It took place in Palm Harbor, Florida, United States between 1 and 7 April 2019.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Nicole Gibbs | 125 | 1 | ||
 Japan | Kurumi Nara | 178 | 2 | |
 Montenegro | Danka Kovinić | 192 | 3 | |
| Whitney Osuigwe | 205 | 4 | ||
| Czech Republic | Barbora Krejčíková | 209 | 5 | |
 Australia | Ellen Perez | 210 | 6 | |
 Italy | Jasmine Paolini | 215 | 7 | |
| Elitsa Kostova | 217 | 8 |
The following players received wildcards into the singles main draw:
Pamela Montez Alycia ParksThe following players received entry from the qualifying draw:
Akgul Amanmuradova Safiya Carrington
Emily Fanning Ingrid Neel Anastasia Nefedova
Laura PigossiThe following player received entry as a lucky loser:
Haruna ArakawaSee main article: 2019 Innisbrook Open – Singles.
Barbora Krejčíková def. Nicole Gibbs, 6–0, 6–1See main article: 2019 Innisbrook Open – Doubles.
Quinn Gleason / Ingrid Neel def. Akgul Amanmuradova / Lizette Cabrera, 5–7, 7–5, [10–8]