| Champ: | Diede de Groot |
| Runner: |  Yui Kamiji |
| Score: | 6–1, 6–0 |
See main article: 2019 French Open.
Diede de Groot defeated the two-time defending champion Yui Kamiji in the final, 6–1, 6–0 to win the women's singles wheelchair tennis title at the 2019 French Open. With the win, de Groot completed a non-calendar-year Grand Slam and the career Grand Slam, becoming the first wheelchair tennis player to do each in singles.