| Date: | 16–22 September |
| Edition: | 8th |
| Draw: | 48S / 16D |
| Surface: | Hard |
| Location: | Columbus, United States |
| Champs: |  Peter Polansky |
| Champd: |  Martin Redlicki / Jackson Withrow |
| Before Name: | Columbus Challenger II |
| Before Year: | 2019 |
| Main Name: | Columbus Challenger |
| After Name: | Columbus Challenger |
The 2019 Columbus Challenger III was a professional tennis tournament played on hard courts. It was the eighth edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Columbus, United States between 16 and 22 September 2019.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Ecuador | Emilio Gómez | 164 | 1 | |
| Mikael Torpegaard | 168 | 2 | ||
| United States | Michael Mmoh | 186 | 3 | |
| Canada | Peter Polansky | 198 | 4 | |
| United States | Thai-Son Kwiatkowski | 206 | 5 | |
 France | Enzo Couacaud | 207 | 6 | |
| United States | Maxime Cressy | 230 | 7 | |
| United States | Donald Young | 242 | 8 | |
| Ecuador | Roberto Quiroz | 249 | 9 | |
 United Kingdom | Liam Broady | 266 | 10 | |
 Argentina | Renzo Olivo | 271 | 11 | |
 Dominican Republic | Roberto Cid Subervi | 281 | 12 | |
| United States | J. J. Wolf | 282 | 13 | |
| Canada | Filip Peliwo | 296 | 14 | |
| United States | Roy Smith | 315 | 15 | |
| United States | Michael Redlicki | 353 | 16 |
The following players received entry into the singles main draw as wildcards:
Justin Boulais Robert Cash Cannon Kingsley Kyle Seelig
James TrotterThe following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Ezekiel Clark Jacob DunbarSee main article: 2019 Columbus Challenger III – Singles.
Peter Polansky def. J. J. Wolf 6–3, 7–6(7–4).See main article: 2019 Columbus Challenger III – Doubles.
Martin Redlicki / Jackson Withrow def. Nathan Pasha / Max Schnur 6–4, 7–6(7–4).