| Date: | 10–16 June |
| Edition: | 7th |
| Draw: | 48S / 16D |
| Surface: | Hard |
| Location: | Columbus, United States |
| Champs: | Mikael Torpegaard |
| Champd: |  Roberto Maytín /  Jackson Withrow |
| Before Name: | Columbus Challenger |
| Before Year: | 2019 |
| After Name: | Columbus Challenger III |
| After Year: | 2019 |
| Main Name: | Columbus Challenger |
The 2019 Columbus Challenger II was a professional tennis tournament played on hard courts. It was the seventh edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Columbus, United States between 10 and 16 June 2019.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United States | Michael Mmoh | 141 | 1 | |
 Japan | Yasutaka Uchiyama | 179 | 2 | |
 Ecuador | Emilio Gómez | 191 | 3 | |
| United States | Donald Young | 193 | 4 | |
 Israel | Dudi Sela | 209 | 6 | |
| Ecuador | Roberto Quiroz | 217 | 7 | |
| Mikael Torpegaard | 218 | 8 | ||
| United States | Tim Smyczek | 224 | 9 | |
 China | Li Zhe | 239 | 10 | |
 Korea, Republic of | Lee Duck-hee | 243 | 11 | |
| United States | Thai-Son Kwiatkowski | 248 | 12 | |
 Canada | Filip Peliwo | 267 | 13 | |
| United States | J. J. Wolf | 270 | 14 | |
| United States | Collin Altamirano | 277 | 15 | |
 Brazil | João Menezes | 287 | 16 |
The following players received entry into the singles main draw as wildcards:
The following players received entry into the singles main draw using protected rankings:
The following player received entry into the singles main draw as an alternate:
The following players received entry into the singles main draw using their ITF World Tennis Ranking:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2019 Columbus Challenger II – Singles.
Nam Ji-sung 6–1, 7–5.See main article: 2019 Columbus Challenger II – Doubles.
Roberto Maytín / Jackson Withrow def. 
Hans Hach Verdugo / Donald Young 6–7(4–7), 7–6(7–2), [10–5].
