| Date: | September 23–29 |
| Edition: | 4th |
| Category: | ATP Tour 250 series |
| Draw: | 28S / 16D |
| Surface: | Hard / outdoor |
| Location: | Chengdu, China |
| Champs: |  Pablo Carreno Busta |
| Champd: |  Nikola Ćaćić / Dušan Lajović |
| After Year: | 2023 |
The 2019 Chengdu Open was a men's tennis tournament played on outdoor hard courts. It was the 4th edition of the Chengdu Open and part of the ATP Tour 250 series of the 2019 ATP Tour. It took place at the Sichuan International Tennis Center in Chengdu, China, from September 23 to 29.
| width=70 | Country | width=175 | Player | Rank1 | Seed |
|---|---|---|---|---|---|
| John Isner | 20 | 1 | |||
 Canada | Félix Auger-Aliassime | 21 | 2 | ||
 France | Benoît Paire | 23 | 3 | ||
| Grigor Dimitrov | 25 | 4 | |||
| Serbia | Dušan Lajović | 29 | 5 | ||
| Taylor Fritz | 30 | 6 | |||
| Kyle Edmund | 32 | 7 | |||
| Canada | Denis Shapovalov | 33 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry using a protected ranking into the singles main draw:
The following player received entry as a special exempt:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Richard Gasquet → replaced by Vasek Pospisil
Mikhail Kukushkin → replaced by 
Ričardas Berankis
Kamil Majchrzak → replaced by Lloyd Harris
Reilly Opelka → replaced by Alexander Bublik Sam Querrey → replaced by 
Márton Fucsovics| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Ivan Dodig |  Slovakia | Filip Polášek | 53 | 1 | ||
 United Kingdom | Dominic Inglot | Austin Krajicek | 85 | 2 | ||
 Mexico | Santiago González |  Sweden | Robert Lindstedt | 111 | 3 | |
 Israel | Jonathan Erlich | France | Fabrice Martin | 129 | 4 |
The following pairs received wildcards into the doubles main draw:
See main article: 2019 Chengdu Open – Singles.
Pablo Carreño Busta def. Alexander Bublik, 6–7(5–7), 6–4, 7–6(7–3)See main article: 2019 Chengdu Open – Doubles.
Nikola Ćaćić / Dušan Lajović def. Jonathan Erlich / Fabrice Martin, 7–6(11–9), 3–6, [10–3]
