| Date: | 28 October–3 November 2019 |
| Edition: | 1st |
| Surface: | Clay |
| Location: | Asunción, Paraguay |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Elisabetta Cocciaretto |
| Champd: |  Andrea Gámiz /  Georgina García Pérez |
The 2019 Centenario Open was a professional tennis tournament played on outdoor clay courts. It was the first edition of the tournament which was part of the 2019 ITF Women's World Tennis Tour. It took place in Asunción, Paraguay between 28 October and 3 November 2019.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Verónica Cepede Royg | 140 | 1 | ||
| Allie Kiick | 151 | 2 | ||
 Colombia | Camila Osorio | 214 | 3 | |
| Conny Perrin | 218 | 4 | ||
 Egypt | Mayar Sherif | 223 | 5 | |
| Italy | Sara Errani | 239 | 6 | |
| Valentini Grammatikopoulou | 248 | 7 | ||
| Katharina Gerlach | 251 | 8 |
The following players received wildcards into the singles main draw:
Carolina AlvesThe following players received entry from the qualifying draw:
Victoria Bosio Guillermina Naya Thaisa Grana Pedretti Teliana Pereira Eduarda Piai Laura Pigossi
Melanie StokkeSee main article: 2019 Centenario Open – Singles.
Elisabetta Cocciaretto def. Sara Errani, 6–1, 4–6, 6–0See main article: 2019 Centenario Open – Doubles.
Andrea Gámiz / Georgina García Pérez def. 
Anna Danilina / Conny Perrin, 6–4, 3–6, [10–3]