| Champ: |  Kei Nishikori |
| Runner: |  Daniil Medvedev |
| Score: | 6–4, 3–6, 6–2 |
| Draw: | 28 (4 / 3) |
| After Year: | 2024 |
| Seeds: | 8 |
See main article: 2019 Brisbane International.
Kei Nishikori defeated Daniil Medvedev in the final, 6–4, 3–6, 6–2 to win the men's singles tennis title at the 2019 Brisbane International. The win ended Nishikori's streak of nine consecutive finals lost on the ATP Tour.
Nick Kyrgios was the defending champion, but lost in the second round to Jérémy Chardy.
The top four seeds receive a bye into the second round.