| Champ: | Diede de Groot |
| Runner: |  Yui Kamiji |
| Score: | 6–0, 6–2 |
| Before Name: | Australian Open – Wheelchair women's singles |
| After Name: | Australian Open – Wheelchair women's singles |
See main article: 2019 Australian Open.
Defending champion Diede de Groot defeated Yui Kamiji in the final, 6–0, 6–2 to win the women's singles wheelchair tennis title at the 2019 Australian Open. It was her third step towards a non-calendar-year Grand Slam.