| Champ: |  Marco Cecchinato |
| Runner: |  Diego Schwartzman |
| Score: | 6–1, 6–2 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Type: | singles doubles |
| Before Name: | Argentina Open – Singles |
| After Name: | Argentina Open – Singles |
See main article: 2019 Argentina Open.
Dominic Thiem was the defending champion, but lost to Diego Schwartzman in the semifinals.[1]
Marco Cecchinato won the title, defeating Schwartzman in the final, 6–1, 6–2.
The top four seeds received a bye into the second round.