| Date: | 5–11 March |
| Edition: | 3rd (ATP) 4th (ITF) |
| Category: | ATP Challenger Tour ITF Women's Circuit |
| Surface: | Hard |
| Location: | Zhuhai, China |
| Venue: | Hengqin International Tennis Center |
| Prize Money: | $75,000+H (ATP) $60,000 (ITF) |
| Champms: |  Alex Bolt |
| Champws: |  Maryna Zanevska |
| Champmd: |  Denys Molchanov /  Igor Zelenay |
| Champwd: |  Anna Blinkova / Lesley Kerkhove |
The 2018 Zhuhai Open was a professional tennis tournament played on hard courts. It was the third (ATP) and fourth (ITF) editions of the tournament and part of the 2018 ATP Challenger Tour and the 2018 ITF Women's Circuit. It took place at the Hengqin International Tennis Center in Zhuhai, China between 5 and 11 March 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Australia | Jordan Thompson | 92 | 1 | |
 Tunisia | Malek Jaziri | 117 | 2 | |
 Spain | Marcel Granollers | 122 | 3 | |
| Oscar Otte | 134 | 4 | ||
| Yannick Maden | 138 | 5 | ||
 Belarus | Ilya Ivashka | 147 | 6 | |
 Estonia | Jürgen Zopp | 148 | 7 | |
| Russian Federation | Alexey Vatutin | 152 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Maverick Banes Alex Bolt
Yusuke Takahashi
Xia Zihao| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Czech Republic | Denisa Allertová | 88 | 1 | |
| Japan | Nao Hibino | 90 | 2 | |
 Thailand | Luksika Kumkhum | 98 | 3 | |
| Slovakia | Viktória Kužmová | 109 | 4 | |
| China | ||||
 Montenegro | Danka Kovinić | 121 | 6 | |
| Japan | Miyu Kato | 127 | 7 | |
| Slovakia | Anna Karolína Schmiedlová | 131 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2018 Zhuhai Open – Men's singles.
Alex Bolt def. 
Hubert Hurkacz, 5–7, 7–6(7–4), 6–2.See main article: 2018 Zhuhai Open – Women's singles.
Maryna Zanevska def. Marta Kostyuk, 6–2, 6–4See main article: 2018 Zhuhai Open – Men's doubles.
Denys Molchanov / Igor Zelenay def. Aliaksandr Bury / Peng Hsien-yin, 7–5, 7–6(7–4).See main article: 2018 Zhuhai Open – Women's doubles.
Anna Blinkova / Lesley Kerkhove def. Nao Hibino / Danka Kovinić, 7–5, 6–4