| Date: | 16–22 April |
| Edition: | 5th |
| Category: | WTA 125K series |
| Location: | Zhengzhou, China |
| Surface: | Hard |
| Prize Money: | $125,000 |
| Champs: |  Zheng Saisai |
| Champd: | Duan Yingying / Wang Yafan |
The 2018 Zhengzhou Women's Tennis Open was a professional tennis tournament played on outdoor hard courts. It was the fifth edition of the tournament and part of the 2018 WTA 125K series, offering a total of $125,000 in prize money. It took place in Zhengzhou, China, on 16–22 April 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| China | ||||
| China | Peng Shuai | 37 | 2 | |
 Thailand | Luksika Kumkhum | 94 | 3 | |
| China | Wang Yafan | 98 | 4 | |
| China | Duan Yingying | 103 | 5 | |
 Belgium | Yanina Wickmayer | 106 | 6 | |
 Japan | Nao Hibino | 122 | 7 | |
| China | Zhu Lin | 129 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry as Lucky Losers:
Lu Jingjing → replaced by Zhang Kailin Zhang Shuai → replaced by You Xiaodi| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Japan | Eri Hozumi | China | Yang Zhaoxuan | 86 | 1 | |
| Japan | Nao Hibino | China | Zheng Saisai | 149 | 2 | |
 United Kingdom | Naomi Broady | Belgium | Yanina Wickmayer | 157 | 3 | |
| China | Duan Yingying | China | Wang Yafan | 220 | 4 |
The following pair received a wildcard into the main draw:
See main article: 2018 Zhengzhou Women's Tennis Open – Singles.
Zheng Saisai def. Wang Yafan 5–7, 6–2, 6–1See main article: 2018 Zhengzhou Women's Tennis Open – Doubles.
Duan Yingying / Wang Yafan def. Naomi Broady / Yanina Wickmayer 7–6(7–5), 6–3