| Date: | 3–9 September |
| Edition: | 8th |
| Category: | ITF Women's Circuit |
| Location: | Zagreb, Croatia |
| Prize Money: | $60,000 |
| Champs: | Tereza Mrdeža |
| Champd: |  Andrea Gámiz / Aymet Uzcátegui |
| Before Year: | 2011 |
The 2018 Zagreb Ladies Open was a professional tennis tournament played on outdoor clay courts. It was the eighth edition of the tournament and was part of the 2018 ITF Women's Circuit. It took place in Zagreb, Croatia, on 3–9 September 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Uzbekistan | Sabina Sharipova | 123 | 1 | |
| Viktoriya Tomova | 142 | 2 | ||
 Spain | Georgina García Pérez | 154 | 3 | |
| Valentini Grammatikopoulou | 169 | 4 | ||
| Elitsa Kostova | 179 | 5 | ||
 Italy | Martina Di Giuseppe | 185 | 6 | |
 Slovakia | Jana Čepelová | 213 | 7 | |
| Tereza Mrdeža | 232 | 8 |
The following players received a wildcard into the singles main draw:
The following players received entry using a protected ranking:
The following players received entry from the qualifying draw:
See main article: 2018 Zagreb Ladies Open – Singles.
Paula Ormaechea, 2–6, 6–4, 7–5See main article: 2018 Zagreb Ladies Open – Doubles.
Andrea Gámiz / Aymet Uzcátegui def. 
Elena Bogdan / Alexandra Cadanțu, 6–3, 6–4
