| Champ: |  Aryna Sabalenka |
| Runner: |  Anett Kontaveit |
| Score: | 6–3, 6–3 |
| Type: | singles doubles |
| Draw: | 56 (8 / 4) |
| Seeds: | 16 |
See main article: article and 2018 Wuhan Open.
Aryna Sabalenka defeated Anett Kontaveit in the final, 6–3, 6–3 to win the singles tennis title at the 2018 Wuhan Open.
Caroline Garcia was the defending champion, but lost in the second round to Kateřina Siniaková.
The top eight seeds received a bye into the second round.