The women's 400 metres freestyle at the 2018 World Para Swimming European Championships was held at the National Aquatic Centre in Dublin from 13 to 19 August. 7 classification finals are held in all over this event.
| S6[1] [2] | 5:19.64 | 5:26.20 | 5:26.97 | ||||
| S7[3] | 5:21.20 | 5:41.33 | 5:56.28 | ||||
| S8[4] | 4:59.51 | 5:04.81 | 5:10.02 | ||||
| S9[5] | 4:42.43 | 4:46.65 | 5:02.07 | ||||
| S10[6] | 4:34.37 | 4:39.65 | 4:40.02 | ||||
| S11[7] | 5:04.74 WR | 5:20.53 | 5:49.94 | ||||
| S12[8] | 4:45.83 | 4:48.70 | 4:53.13 | ||||