The men's 400 metres freestyle at the 2018 World Para Swimming European Championships was held at the National Aquatic Centre in Dublin from 13 to 19 August. 8 classification finals are held in all over this event.
| S6[1] [2] | 5:09.96 | 5:24.12 | 5:39.88 | ||||
| S7[3] | 4:48.54 | 4:48.69 | 4:51.40 | ||||
| S8[4] | 4:40.78 | 4:59.97 | 5:00.26 | ||||
| S9[5] | 4:16.92 | 4:18.30 | 4:23.70 | ||||
| S10[6] | 4:01.86 | 4:03.89 | 4:06.61 | ||||
| S11[7] | 5:01.63 | 5:17.56 | 5:17.86 | ||||
| S12[8] | 4:08.00 | 4:22.75 | 4:36.11 | ||||
| S13[9] | 4:01.12 | 4:03.01 | 4:13.04 | ||||