The men's 400 metres at the 2018 World Para Athletics European Championships was held at the Friedrich-Ludwig-Jahn Sportpark in Berlin from 20 to 26 August.
| T11[1] | guide : Guillermo Rojo Gil | 50.65 CR | guide : Mehmet Tetik | 55.59 | no medal awarded | ||
| T12[2] | 49.92 CR | 50.33 | 50.40 | ||||
| T13[3] | 52.32 | 53.32 | 53.90 | ||||
| T20[4] | 49.60 | 50.86 | 52.16 | ||||
| T34[5] | 54.40 CR | 55.92 | 56.31 | ||||
| T36[6] | 55.90 | 58.81 | 1:03.17 | ||||
| T37[7] | 53.31 | 54.82 | 56.32 | ||||
| T38[8] | 55.71 | 56.82 | no medal awarded | ||||
| T47[9] | 50.34 | 50.98 | 51.49 | ||||
| T52[10] | 1:08.39 | 1:08.45 | 1:09.54 | ||||
| T53[11] | 50.47 | 51.91 | 53.03 | ||||
| T54[12] | 46.73 | 49.20 | 51.15 | ||||
| T62[13] | 47.93 | 55.26 | 57.52 | ||||