| Champ: | Diede de Groot |
| Runner: | Aniek van Koot |
| Score: | 6–3, 6–2 |
| After Name: | Wimbledon Championships – Wheelchair women's singles |
| Before Name: | Wimbledon Championships – Wheelchair women's singles |
See main article: 2018 Wimbledon Championships.
Defending champion Diede de Groot defeated Aniek van Koot in the final, 6–3, 6–2 to win the ladies' singles wheelchair tennis title at the 2018 Wimbledon Championships. It was her first step towards a non-calendar-year Grand Slam.
Yui Kamiji (semifinals)