| Champ: | Kiki Bertens |
| Runner: | Julia Görges |
| Score: | 6–2, 6–1 |
| Draw: | 56 |
| Seeds: | 16 |
| Type: | singles doubles |
| Before Name: | Volvo Car Open – Singles |
| After Name: | Volvo Car Open – Singles |
| Main Name: | Charleston Open |
See main article: 2018 Volvo Car Open. Daria Kasatkina was the defending champion, but lost in the quarterfinals to Julia Görges.
Kiki Bertens won the title, despite being a match point down in the third set of her semifinal clash with Madison Keys. Bertens beat Görges in the final, 6–2, 6–1.
The top eight seeds received a bye into the second round.
