See main article: 2018 US Open (tennis).
Dylan Alcott defeated the defending champion David Wagner in the final, 7–5, 6–2 to win the quad singles wheelchair tennis title at the 2018 US Open.
Standings are determined by: 1. number of wins; 2. number of matches; 3. in two-players-ties, head-to-head records; 4. in three-players-ties, percentage of sets won, or of games won; 5. steering-committee decision.