| Date: | 16–22 April |
| Edition: | 10th |
| Draw: | 32S / 16D |
| Surface: | Clay |
| Location: | Tunis, Tunisia |
| Champs: |  Guido Andreozzi |
| Champd: |  Denys Molchanov /  Igor Zelenay |
| Before Year: | 2014 |
The 2018 Tunis Open was a professional tennis tournament played on clay courts. It was the tenth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Tunis, Tunisia between 16 and 22 April 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Czech Republic | ||||
 Georgia | Nikoloz Basilashvili | 86 | 2 | |
 Tunisia | Malek Jaziri | 91 | 3 | |
 Moldova, Republic of | Radu Albot | 93 | 4 | |
 Italy | Thomas Fabbiano | 102 | 5 | |
| Gastão Elias | 106 | 6 | ||
| Pedro Sousa | 118 | 7 | ||
 Sweden | Elias Ymer | 134 | 8 |
The following players received wildcards into the singles main draw:
Mohamed Ali Bellalouna Moez Echargui
Lamine Ouahab
Alexei PopyrinThe following player received entry into the singles main draw as a special exempt:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2018 Tunis Open – Singles.
Guido Andreozzi def. 
Daniel Gimeno Traver 6–2, 3–0 ret.See main article: 2018 Tunis Open – Doubles.
Denys Molchanov / Igor Zelenay def. 
Jonathan Eysseric / 
Joe Salisbury 7–6(7–4), 6–2.