The 2018 Thindown Challenger Biella was a professional tennis tournament played on outdoor red clay courts. It was part of the 2018 ATP Challenger Tour. It took place in Biella, Italy between 17 and 23 September 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Roberto Carballés Baena | 94 | 1 | |
 Argentina | Federico Delbonis | 100 | 2 | |
 Italy | Paolo Lorenzi | 113 | 3 | |
 Brazil | Thiago Monteiro | 117 | 4 | |
| Argentina | Marco Trungelliti | 134 | 5 | |
| Italy | Stefano Travaglia | 147 | 6 | |
| Gastão Elias | 154 | 7 | ||
| Spain | Daniel Gimeno Traver | 158 | 8 |
The following players received wildcards into the singles main draw:
Enrico Dalla Valle Paolo Lorenzi Andrea Pellegrino Pietro RondoniThe following players received entry into the singles main draw as special exempts:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Oscar José Gutierrez
Juan Pablo VarillasSee main article: 2018 Thindown Challenger Biella – Singles.
Federico Delbonis def. Stefano Napolitano 6–4, 6–3.See main article: 2018 Thindown Challenger Biella – Doubles.
Fabrício Neis / David Vega Hernández def. 
Rameez Junaid / 
Purav Raja 6–4, 6–4.
