| Champ: |  Gilles Simon |
| Runner: | Kevin Anderson |
| Score: | 7–6(7–4), 6–2 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Type: | singles doubles |
| Before Name: | Aircel Chennai Open – Singles |
| Main Name: | Maharashtra Open |
See main article: 2018 Tata Open Maharashtra.
Roberto Bautista Agut was the defending champion, but lost in the second round to Gilles Simon.
Simon went on to win the title, defeating Kevin Anderson in the final, 7–6(7–4), 6–2.
The top four seeds receive a bye into the second round.