| Champ: |  Margarita Gasparyan |
| Runner: | Anastasia Potapova |
| Score: | 6–2, 6–1 |
| Draw: | 32 |
| Seeds: | 8 |
| Type: | singles doubles |
See main article: article and 2018 Tashkent Open.
Kateryna Bondarenko was the defending champion, but chose not to participate.
Margarita Gasparyan won the title, defeating qualifier and compatriot Anastasia Potapova in the final 6–2, 6–1. Ranked at World No. 299, Gasparyan became the third-lowest ranked player ever to win a WTA singles title.