| Date: | 8–13 October |
| Edition: | 11th |
| Surface: | Hard |
| Location: | Tashkent, Uzbekistan |
| Champs: |  Félix Auger-Aliassime |
| Champd: |  Sanjar Fayziev / Jurabek Karimov |
The 2018 Tashkent Challenger was a professional tennis tournament played on hard courts. It was the eleventh edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Tashkent, Uzbekistan between 8 and 13 October 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Bosnia and Herzegovina | Mirza Bašić | 77 | 1 | |
| Uzbekistan | Denis Istomin | 103 | 2 | |
 Spain | Enrique López Pérez | 167 | 3 | |
 Czech Republic | ||||
 Russian Federation | Alexey Vatutin | 178 | 5 | |
 Poland | Kamil Majchrzak | 181 | 6 | |
| Daniel Brands | 185 | 7 | ||
 Egypt | Mohamed Safwat | 196 | 8 |
The following players received wildcards into the singles main draw:
Alen Avidzba Jurabek Karimov Khumoyun Sultanov Dimitriy VoroninThe following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2018 Tashkent Challenger – Singles.
Félix Auger-Aliassime def. Kamil Majchrzak 6–3, 6–2.See main article: 2018 Tashkent Challenger – Doubles.
Sanjar Fayziev / Jurabek Karimov def. 
Federico Gaio / Enrique López Pérez 6–2, 6–7(3–7), [11–9].
