| Date: | 29 October–4 November |
| Edition: | 2nd |
| Category: | ITF Women's Circuit |
| Location: | Tyler, United States |
| Surface: | Hard |
| Prize Money: | $80,000 |
| Champs: |  Whitney Osuigwe |
| Champd: | Nicole Gibbs / Asia Muhammad |
The 2018 RBC Pro Challenge was a professional tennis tournament played on outdoor hard courts. It was the second edition of the tournament and was part of the 2018 ITF Women's Circuit. It took place in Tyler, United States, on 29 October–4 November 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Belinda Bencic | 37 | 1 | ||
| United States | Madison Brengle | 89 | 2 | |
 Hungary | Fanny Stollár | 127 | 3 | |
| United States | Jessica Pegula | 129 | 4 | |
| United States | Claire Liu | 139 | 5 | |
| United States | Nicole Gibbs | 143 | 6 | |
| United States | Kristie Ahn | 145 | 7 | |
| United States | Christina McHale | 153 | 8 |
The following players received a wildcard into the singles main draw:
The following player received entry using a protected ranking:
The following player received entry using a junior exempt:
The following players received entry from the qualifying draw:
Ellie Douglas Quinn Gleason Ann Li
Bianca TuratiSee main article: 2018 RBC Pro Challenge – Singles.
Whitney Osuigwe def. 
Beatriz Haddad Maia, 6–3, 6–4See main article: 2018 RBC Pro Challenge – Doubles.
Nicole Gibbs / Asia Muhammad def. Desirae Krawczyk / 
Giuliana Olmos, 3–6, 6–3, [14–12]