| Date: | February 26 – March 4 |
| Edition: | 1st |
| Draw: | 32S / 16D |
| Surface: | Hard, outdoor |
| Prize Money: | $150,000+H (ATP) $150,000 (WTA) |
| Category: | ATP Challenger Tour WTA 125K series |
| Location: | Indian Wells, United States |
| Venue: | Indian Wells Tennis Garden |
| Champmd: |  Austin Krajicek / Jackson Withrow |
| Champws: |  Sara Errani |
The 2018 Oracle Challenger Series – Indian Wells is a professional tennis tournament played on outdoor hard courts. This tournament is part of the 2018 ATP Challenger Tour and the 2018 WTA 125K series. The first edition took place on February 26 through March 4, 2018, in Indian Wells, United States.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Romania | Marius Copil | 73 | 1 | |
 Bosnia and Herzegovina | Mirza Bašić | 74 | 2 | |
 Canada | Vasek Pospisil | 83 | 3 | |
| Taylor Fritz | 85 | 4 | ||
 Russian Federation | Mikhail Youzhny | 93 | 6 | |
 France | Jérémy Chardy | 96 | 7 | |
 Israel | Dudi Sela | 97 | 8 | |
| Yannick Hanfmann | 117 | 9 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Poland | Magda Linette | 55 | 1 | |
| Varvara Lepchenko | 66 | 2 | ||
| Hsieh Su-wei | 69 | 3 | ||
 Ukraine | Kateryna Bondarenko | 78 | 4 | |
| Jennifer Brady | 88 | 5 | ||
| Italy | Francesca Schiavone | 93 | 6 | |
| Russian Federation | Natalia Vikhlyantseva | 94 | 7 | |
 China | Duan Yingying | 96 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Ekaterina Alexandrova → replaced by Kristie Ahn Monica Niculescu → replaced by Evgeniya Rodina
Naomi Osaka → replaced by Richèl Hogenkamp| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Romania | Raluca Olaru | Ukraine | Olga Savchuk | 97 | 1 | |
 Czech Republic | Barbora Krejčíková |  Belarus | Vera Lapko | 135 | 2 | |
| Jennifer Brady | Vania King | 178 | 3 | |||
| China | Duan Yingying | China | Wang Yafan | 218 | 4 |
The following team received wildcard into the doubles main draw:
See main article: article and 2018 Oracle Challenger Series – Indian Wells – Men's singles.
Martin Kližan def. Darian King 6–3, 6–3.See main article: article and 2018 Oracle Challenger Series – Indian Wells – Women's singles.
Sara Errani def. Kateryna Bondarenko 6–4, 6–2See main article: article and 2018 Oracle Challenger Series – Indian Wells – Men's doubles.
Austin Krajicek / Jackson Withrow def. Evan King / Nathan Pasha 6–7(3–7), 6–1, [11–9].See main article: article and 2018 Oracle Challenger Series – Indian Wells – Women's doubles.
Taylor Townsend / 
Yanina Wickmayer def. Jennifer Brady / Vania King 6–4, 6–4
