The 2018 Open de Guadeloupe was a professional tennis tournament played on hard courts. It was the seventh edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Le Gosier, Guadeloupe between 27 March and 1 April 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Stefanos Tsitsipas | 70 | 1 | ||
| Gastão Elias | 106 | 2 | ||
 Serbia | Dušan Lajović | 108 | 3 | |
 Belgium | Ruben Bemelmans | 116 | 4 | |
 Canada | Peter Polansky | 126 | 5 | |
| Denis Kudla | 144 | 6 | ||
 France | Calvin Hemery | 150 | 7 | |
| Bradley Klahn | 163 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Sander Gillé Tom Jomby Laurent Rochette
Evan SongSee main article: 2018 Open de Guadeloupe – Singles.
Dušan Lajović def. Denis Kudla 6–4, 6–0.See main article: 2018 Open de Guadeloupe – Doubles.
Neal Skupski / 
John-Patrick Smith def. Ruben Bemelmans / John-Patrick Smith 7–6(7–3), 6–4.
