| Date: | 30 April–5 May |
| Edition: | 3rd |
| Category: | ITF Women's Circuit |
| Location: | Khimki, Russia |
| Surface: | Hard / Indoor |
| Prize Money: | $100,000 |
| Champs: |  Vera Lapko |
| Champd: |  Olga Doroshina / Anastasiya Komardina |
The 2018 O1 Properties Ladies Cup was a professional tennis tournament played on indoor hard courts. It was the third edition of the tournament and was part of the 2018 ITF Women's Circuit. It took place in Khimki, Russia, on 30 April–5 May 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Romania | Monica Niculescu | 63 | 1 | |
| Belarus | Vera Lapko | 111 | 2 | |
| Russian Federation | Evgeniya Rodina | 118 | 3 | |
 Australia | Arina Rodionova | 131 | 4 | |
| Russian Federation | Vitalia Diatchenko | 173 | 5 | |
| Valentini Grammatikopoulou | 175 | 6 | ||
| Russian Federation | Polina Monova | 196 | 7 | |
 Serbia | Ivana Jorović | 241 | 8 |
The following players received a wildcard into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2018 O1 Properties Ladies Cup – Singles.
Vera Lapko def. Anastasia Potapova, 6–1, 6–3 Olga Doroshina / Anastasiya Komardina def. Veronika Pepelyaeva / Anastasia Tikhonova, 6–1, 6–2