| Champ: | Kevin Anderson |
| Runner: |  Sam Querrey |
| Score: | 4–6, 6–3, 7–6(7–1) |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Edition: | 1st |
| Type: | singles doubles |
| Main Name: | New York Open (tennis) |
| After Name: | New York Open |
See main article: article and 2018 New York Open.
This was the first edition of the tournament.
Kevin Anderson won the title, defeating Sam Querrey in the final, 4–6, 6–3, 7–6(7–1).
The top four seeds receive a bye into the second round.