See main article: article and 2018 Monterrey Challenger.
Christopher Eubanks and Evan King were the defending champions but only King chose to defend his title, partnering Nathan Pasha. King lost in the first round to Thanasi Kokkinakis and Matt Reid.
Marcelo Arévalo and Jeevan Nedunchezhiyan won the title after defeating Leander Paes and Miguel Ángel Reyes-Varela 6–1, 6–4 in the final.