| Date: | 22–28 October |
| Edition: | 6th |
| Category: | ITF Women's Circuit |
| Location: | Macon, United States |
| Surface: | Hard |
| Prize Money: | $80,000 |
| Champs: |  Varvara Lepchenko |
| Champd: | Caty McNally / Jessica Pegula |
| Main Name: | Tennis Classic of Macon |
| Before Name: | Tennis Classic of Macon |
The 2018 Mercer Tennis Classic was a professional tennis tournament played on outdoor hard courts. It was the sixth edition of the tournament and was part of the 2018 ITF Women's Circuit. It took place in Macon, United States, on 22–28 October 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United States | Madison Brengle | 88 | 1 | |
| United States | Jessica Pegula | 129 | 2 | |
 Russian Federation | Sofya Zhuk | 134 | 3 | |
| United States | Claire Liu | 140 | 4 | |
| United States | Nicole Gibbs | 145 | 5 | |
| United States | Kristie Ahn | 147 | 6 | |
 Czech Republic | Marie Bouzková | 151 | 7 | |
| United States | Christina McHale | 154 | 8 |
The following players received a wildcard into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2018 Mercer Tennis Classic – Singles.
Varvara Lepchenko def. Verónica Cepede Royg, 6–4, 6–4See main article: 2018 Mercer Tennis Classic – Doubles.
Caty McNally / Jessica Pegula def. 
Anna Danilina / Ingrid Neel, 6–1, 5–7, [11–9]