See main article: article and 2018 Los Cabos Open.
Juan Sebastián Cabal and Treat Huey were the defending champions, but Huey chose not to participate and Cabal chose to compete in Washington instead.
Marcelo Arévalo and Miguel Ángel Reyes-Varela won the title, defeating Taylor Fritz and Thanasi Kokkinakis in the final, 6–4, 6–4.