| Champ: |  Elise Mertens |
| Runner: |  Aryna Sabalenka |
| Score: | 7–5, 6–2 |
| Type: | singles doubles |
| Before Name: | Ladies Open Biel Bienne |
See main article: 2018 Ladies Open Lugano.
Elise Mertens defeated Aryna Sabalenka in the final, 7–5, 6–2, to win the singles title at the 2018 Ladies Open Lugano.
Markéta Vondroušová was the defending champion, but lost in the second round to Mertens.