| Date: | 30 April–6 May |
| Edition: | 2nd |
| Category: | ITF Women's Circuit |
| Location: | Charleston, United States |
| Surface: | Clay |
| Prize Money: | $80,000 |
| Champs: |  Taylor Townsend |
| Champd: | Alexa Guarachi /  Erin Routliffe |
The 2018 LTP Charleston Pro Tennis was a professional tennis tournament played on outdoor clay courts. It was the second edition of the tournament and was part of the 2018 ITF Women's Circuit. It took place in Charleston, United States, on 30 April–6 May 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United States | Madison Brengle | 80 | 1 | |
| United States | Taylor Townsend | 91 | 2 | |
 Colombia | Mariana Duque Mariño | 112 | 3 | |
| United States | Nicole Gibbs | 119 | 4 | |
| United States | Kristie Ahn | 127 | 5 | |
 Ukraine | Anhelina Kalinina | 151 | 6 | |
| United States | Jamie Loeb | 163 | 7 | |
| United States | Irina Falconi | 167 | 8 |
The following players received a wildcard into the singles main draw:
The following player received entry using a protected ranking:
The following player received entry using a junior exempt:
The following players received entry from the qualifying draw:
See main article: 2018 LTP Charleston Pro Tennis – Singles.
Taylor Townsend def. Madison Brengle, 6–0, 6–4 Erin Routliffe def. Louisa Chirico / Allie Kiick, 6–1, 3–6, [10–5]
