| Champ: |  Karen Khachanov |
| Runner: |  Adrian Mannarino |
| Score: | 6–2, 6–2 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Before Name: | Kremlin Cup – Men's singles |
| After Name: | Kremlin Cup – Men's singles |
See main article: article and 2018 Kremlin Cup.
Damir Džumhur was the defending champion, but lost to Egor Gerasimov in the first round.
Karen Khachanov won the title, defeating Adrian Mannarino in the final, 6–2, 6–2.
The top four seeds received a bye into the second round.
