See main article: article and 2018 Knoxville Challenger.
Filip Peliwo was the defending champion but chose not to defend his title.
Reilly Opelka won the title after defeating Bjorn Fratangelo 7–5, 4–6, 7–6(7–2) in the final.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "2018 Knoxville Challenger – Singles".
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