| Date: | 30 July–5 August |
| Edition: | 23rd (ATP) 21st (ITF) |
| Category: | ATP Challenger Tour ITF Women's Circuit |
| Location: | Lexington, United States |
| Prize Money: | $75,000 (ATP) $60,000 (ITF) |
| Champms: | Lloyd Harris |
| Champws: |  Asia Muhammad |
| Champmd: | Robert Galloway /  Roberto Maytín |
| Champwd: | Hayley Carter / Ena Shibahara |
| Main Name: | Lexington Challenger |
The 2018 Kentucky Bank Tennis Championships was a professional tennis tournament played on outdoor hard courts. It was the twenty-third (ATP) and twenty-first (ITF) editions of the tournament and was part of the 2018 ATP Challenger Tour and the 2018 ITF Women's Circuit. It took place in Lexington, United States, on 30 July–5 August 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | ||||
 Australia | Marc Polmans | 179 | 2 | |
 Slovakia | Norbert Gombos | 182 | 3 | |
 United Kingdom | Liam Broady | 184 | 4 | |
| Australia | Max Purcell | 215 | 5 | |
| Lloyd Harris | 216 | 6 | ||
| United Kingdom | Jay Clarke | 225 | 7 | |
 Italy | Stefano Napolitano | 240 | 8 |
The following players received a wildcard into the singles main draw:
Collin Altamirano William Bushamuka
Tom Jomby Sam RifficeThe following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Arantxa Rus | 105 | 1 | ||
| Australia | Arina Rodionova | 144 | 2 | |
| Australia | Lizette Cabrera | 151 | 3 | |
 Czech Republic | Marie Bouzková | 161 | 4 | |
| United States | Grace Min | 169 | 5 | |
| United Kingdom | Gabriella Taylor | 178 | 6 | |
 Israel | Julia Glushko | 196 | 7 | |
| Australia | Jaimee Fourlis | 206 | 8 |
The following players received a wildcard into the singles main draw:
The following player received entry using a protected ranking:
The following player received entry by a special exempt:
The following players received entry from the qualifying draw:
Alison Bai Sanaz Marand Anastasia Nefedova Kennedy ShafferSee main article: 2018 Kentucky Bank Tennis Championships – Men's singles.
Stefano Napolitano 6–4, 6–3.See main article: 2018 Kentucky Bank Tennis Championships – Women's singles.
Asia Muhammad def. Ann Li, 7–5, 6–1See main article: 2018 Kentucky Bank Tennis Championships – Men's doubles.
Robert Galloway / Roberto Maytín def. 
Joris De Loore / Marc Polmans 6–3, 6–1.See main article: 2018 Kentucky Bank Tennis Championships – Women's doubles.
Hayley Carter / Ena Shibahara def. Sanaz Marand / 
Victoria Rodríguez, 6–3, 6–1