The 2018 Karshi Challenger was a professional tennis tournament played on hard courts. It was the twelfth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Qarshi, Uzbekistan between 7 and 12 May 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Poland | Hubert Hurkacz | 178 | 1 | |
 Serbia | Nikola Milojević | 208 | 2 | |
 Belarus | Egor Gerasimov | 224 | 3 | |
| Belarus | Uladzimir Ignatik | 226 | 4 | |
 Kazakhstan | Aleksandr Nedovyesov | 228 | 5 | |
| Lloyd Harris | 232 | 6 | ||
 Bosnia and Herzegovina | Aldin Šetkić | 245 | 7 | |
| Yang Tsung-hua | 249 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Sergey Betov
Tristan Lamasine
Sasikumar Mukund
Shuichi SekiguchiSee main article: 2018 Karshi Challenger – Singles.
Egor Gerasimov def. Sergey Betov 7–6(7–3), 2–0 ret.See main article: 2018 Karshi Challenger – Doubles.
Timur Khabibulin / 
Vladyslav Manafov def. 
Sanjar Fayziev / Jurabek Karimov 6–2, 6–1.