| Date: | 16–22 April |
| Edition: | 8th |
| Draw: | 32S / 16D |
| Surface: | Hard |
| Location: | Guadalajara, Mexico |
| Champs: | Marcelo Arévalo |
| Champd: | Marcelo Arévalo /  Miguel Ángel Reyes-Varela |
| After Year: | no |
The 2018 Jalisco Open was a professional tennis tournament played on hard courts. It was the eighth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Guadalajara, Mexico between 16 and 22 April 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Adrián Menéndez Maceiras | 141 | 1 | |
| Mats Moraing | 156 | 2 | ||
| Dennis Novikov | 167 | 3 | ||
 Canada | Filip Peliwo | 169 | 4 | |
| Kevin King | 171 | 5 | ||
| Marcelo Arévalo | 174 | 6 | ||
 Dominican Republic | Víctor Estrella Burgos | 177 | 7 | |
| Darian King | 183 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
See main article: 2018 Jalisco Open – Singles.
Christopher Eubanks 6–4, 5–7, 7–6(7–4).See main article: 2018 Jalisco Open – Doubles.
Miguel Ángel Reyes-Varela def. 
Brydan Klein / Ruan Roelofse 7–6(7–3), 7–5.
