| Date: | 12 November – 17 November |
| Edition: | 23rd |
| Surface: | Hard |
| Location: | Champaign, Illinois, United States |
| Champs: |  Reilly Opelka |
| Champd: |  Matt Reid / John-Patrick Smith |
The 2018 JSM Challenger of Champaign–Urbana was a professional tennis tournament played on hard courts. It was the twenty-third edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Champaign, Illinois, United States between November 12 and November 17, 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Marcel Granollers | 96 | 1 | |
 France | Ugo Humbert | 98 | 2 | |
 Canada | Peter Polansky | 120 | 3 | |
| Reilly Opelka | 134 | 4 | ||
| Henri Laaksonen | 163 | 5 | ||
 Serbia | Nikola Milojević | 172 | 6 | |
| Christopher Eubanks | 188 | 7 | ||
| Australia | John-Patrick Smith | 202 | 8 |
The following players received wildcards into the singles main draw:
Alexander Brown Ezekiel Clark Sebastian Korda Patrick KypsonThe following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Keenan Mayo Ryan ShaneThe following player received entry as a lucky loser:
Alafia AyeniSee main article: article and 2018 JSM Challenger of Champaign–Urbana – Singles.
Reilly Opelka def. Ryan Shane 7–6(8–6), 6–3.See main article: article and 2018 JSM Challenger of Champaign–Urbana – Doubles.
Matt Reid / John-Patrick Smith def. 
Hans Hach Verdugo / 
Luis David Martínez 6–4, 4–6, [10–8].