The 2018 Internazionali di Tennis Città di Perugia was a professional tennis tournament played on clay courts. It was the fourth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Perugia, Italy between 10 and 15 July 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Austria | Gerald Melzer | 106 | 1 | |
 Spain | Pablo Andújar | 123 | 2 | |
| Spain | Enrique López Pérez | 159 | 4 | |
 Serbia | Nikola Milojević | 162 | 5 | |
 Italy | Matteo Donati | 176 | 6 | |
 Hungary | Attila Balázs | 182 | 7 | |
| Spain | Carlos Taberner | 185 | 8 | |
 France | Kenny de Schepper | 187 | 9 |
The following players received wildcards into the singles main draw:
Nicolás Almagro Pablo Andújar Jacopo Berrettini Enrico Dalla ValleThe following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2018 Internazionali di Tennis Città di Perugia – Singles.
Ulises Blanch def. Gianluigi Quinzi 7–5, 6–2.See main article: 2018 Internazionali di Tennis Città di Perugia – Doubles.
Daniele Bracciali / Matteo Donati def. 
Tomislav Brkić / Ante Pavić 6–3, 3–6, [10–7].
